AstraZeneca

Dapagliflozin for cardiorenal protection after intensive care unit discharge: a protocol for a randomised controlled trial evaluating dapagliflozin at ICU discharge for cardiorenal protection (DAPA-ICU).

DAPA-ICU will test dapagliflozin versus placebo for one year in 600 adults at high cardiorenal risk following ICU discharge, targeting a composite of death, heart failure hospitalization, and renal decline. Multicentre, double-blind RCT across 16 French ICUs enrolling mechanically ventilated patients with elevated cardiac or renal biomarkers. This represents the first trial extending SGLT2 inhibitor cardiorenal protection to critically ill survivors, a population with 22% one-year mortality. Single-country study limits global generalizability.